WAKIX PrescriptionPharmacokinetic (PK) and Drug Interaction Information for WAKIX
WAKIX had no clinically important PK interactions with modafinil or sodium oxybate
- In a clinical PK study in adults to evaluate the concomitant use of WAKIX with modafinil or sodium oxybate, WAKIX had no effect on the PK of modafinil or sodium oxybate, and these agents had no clinically relevant effect on the PK of WAKIX1
Effect of WAKIX on modafinil
WAKIX had no effect on the PK of modafinil
Effect of modafinil on WAKIX
Modafinil had no clinically relevant effect on the PK of WAKIX
*Seventeen healthy male adult subjects received treatment with a single dose of 35.6 mg WAKIX on Day 1, modafinil 200 mg/day from Day 5 to Day 25, and a single dose of 35.6 mg WAKIX plus 200 mg modafinil on Day 26.1
*Seventeen healthy male adult subjects received treatment with a single dose of 35.6 mg WAKIX on Day 1, modafinil 200 mg/day from Day 5 to Day 25, and a single dose of 35.6 mg WAKIX plus 200 mg modafinil on Day 26.1
| Some medications have clinically important drug interactions with WAKIX | |
|---|---|
| Effect of Other Drugs on WAKIX | |
| Strong CYP2D6 Inhibitors | Strong CYP2D6 Inhibitors
|
| Strong CYP3A4 Inducers | Strong CYP3A4 Inducers
|
| Histamine 1 (H1) Receptor Antagonists | Histamine 1
|
| Drugs Known to Prolong QT Interval | Drugs Known to Prolong
|
| Effect of WAKIX on Other Drugs | |
| Sensitive CYP3A4 Substrates | Sensitive CYP3A4 Substrates
|
See Full Prescribing Information for prevention or management of drug interactions.
The PK profile of WAKIX supports once-daily dosing
- Median t1/2 ~20 hours (7.5 to 24.2 hours) after a single 35.6-mg dose
- Median Tmax 3.5 hours (2 to 5 hours)
t1/2, half-life; Tmax, time to maximum concentration.
Dosing WAKIX with other medications
Some medications have clinically important drug interactions with WAKIX. Identify drug interactions and recommendations for dosing WAKIX with other medications.
