Pharmacokinetic (PK) and Drug Interaction Information for WAKIX
The PK profile of WAKIX supports once-daily dosing
- Median t1/2 ~20 hours (7.5 to 24.2 hours) after a single 35.6-mg dose
- Median Tmax 3.5 hours (2 to 5 hours)
- No clinically significant PK differences were observed following administration with a high-fat meal
t1/2, half-life; Tmax, time to maximum concentration.
WAKIX had no clinically important PK interactions with modafinil or sodium oxybate
- In a clinical PK study to evaluate the concomitant use of WAKIX with modafinil or sodium oxybate, WAKIX had no effect on the PK of modafinil or sodium oxybate, and these agents had no clinically relevant effect on the PK of WAKIX
|Some medications have clinically important drug interactions with WAKIX|
|Effect of Other Drugs on WAKIX|
|Strong CYP2D6 Inhibitors|
|Strong CYP3A4 Inducers|
|Histamine 1 (H1) Receptor Antagonists|
|Drugs Known to Prolong QT Interval|
|Effect of WAKIX on Other Drugs|
|Sensitive CYP3A4 Substrates|
See Full Prescribing Information for prevention or management of drug interactions.
Dosing WAKIX with other medications
Some medications have clinically important drug interactions with
WAKIX. Identify drug interactions and recommendations for dosing
WAKIX with other medications.