Histamine Plays an Important Role in Promoting and Stabilizing Wakefulness1-3

In the brain, histamine acts as a key wake-promoting neurotransmitter1,4

  • Histamine is synthesized in the presynaptic neuron1
  • When released into the synapse, histamine binds to postsynaptic H1 receptors1

Histamine neuronal activity in the brain is modulated by H1 and H3 receptors1

  • H1 receptors increase neuronal activity, which allows for communication with important brain regions for sleep and wakefulness1-3
  • H3 receptors are found primarily in the brain and help regulate histamine synthesis and release5,6
    • ­Normally, when histamine levels in the brain are high, histamine binds to H3 autoreceptors to inhibit further synthesis and release of histamine in the brain5

Hypocretin (also known as orexin) and histamine play complementary roles in wakefulness7

  • Hypocretin and histamine neurons in the brain originate only in the hypothalamus and play important roles in promoting and stabilizing wakefulness1-4
Histamine neuron activity image

The Role of Histamine in Promoting Wakefulness

Watch this video to learn about the role of histamine in the brain and the importance of histamine in promoting wakefulness.

The role of histamine in promoting wakefulness video thumbnail